| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UGT1A1 (1-200) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UGT1A1 |
| Gene ID: |
54658 |
| Uniprot ID: |
UD11_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1 (NP_000454.1). |
| Immunogen Sequence: |
MAVESQGGRPLVLGLLLCVL GPVVSHAGKILLIPVDGSHW LSMLGAIQQLQQRGHEIVVL APDASLYIRDGAFYTLKTYP VPFQREDVKESFVSLGHNVF ENDSFLQRVIKTYKKIKKDS AMLLSGCSHLLHNKELMASL AESSFDVMLTDPFLPCSPIV AQYLSLPTVFFLHALPCSLE FEATQCPNPFSYVPRPLSSH |
| Tissue Specificity | Isoform 1: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin. Isoform 2: Expressed in liver, colon, small intestine and kidney. Not expressed in esophagus and skin. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a1Ugt1a1Bilirubin-Specific Udpgt Isozyme 1Hug-Br1Udp-Glucuronosyltransferase 1-1Udpgt 1-1Ugt1*1Ugt1-01Ugt1.1Udp-Glucuronosyltransferase 1a Isoform 1 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-189483Reactome: R-HSA-5579002Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a1 antibodyAnti-Ugt1a1 antibodyAnti-Bilirubin-Specific Udpgt Isozyme 1 antibodyAnti-Hug-Br1 antibodyAnti-Udp-Glucuronosyltransferase 1-1 antibodyAnti-Udpgt 1-1 antibodyAnti-Ugt1*1 antibodyAnti-Ugt1-01 antibodyAnti-Ugt1.1 antibodyAnti-Udp-Glucuronosyltransferase 1a Isoform 1 antibodyAnti-UGT1A1 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
