| Function | Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. |
| Protein Name | Udp-Glucose 4-EpimeraseGalactowaldenaseUdp-N-Acetylgalactosamine 4-EpimeraseUdp-Galnac 4-EpimeraseUdp-N-Acetylglucosamine 4-EpimeraseUdp-Glcnac 4-EpimeraseUdp-Galactose 4-Epimerase |
| Database Links | Reactome: R-HSA-5609977Reactome: R-HSA-70370 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Udp-Glucose 4-Epimerase antibodyAnti-Galactowaldenase antibodyAnti-Udp-N-Acetylgalactosamine 4-Epimerase antibodyAnti-Udp-Galnac 4-Epimerase antibodyAnti-Udp-N-Acetylglucosamine 4-Epimerase antibodyAnti-Udp-Glcnac 4-Epimerase antibodyAnti-Udp-Galactose 4-Epimerase antibodyAnti-GALE antibody |
Information sourced from Uniprot.org
