Anti-GALE antibody (129-348) (STJ28678)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GALE (129-348) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GALE |
| Gene ID | 2582 |
| Uniprot ID | GALE_HUMAN |
| Immunogen Region | 129-348 |
| Immunogen Sequence | FSSSATVYGNPQYLPLDEAH PTGGCTNPYGKSKFFIEEMI RDLCQADKTWNAVLLRYFNP TGAHASGCIGEDPQGIPNNL MPYVSQVAIGRREALNVFGN DYDTEDGTGVRDYIHVVDLA KGHIAALRKLKEQCGCRIYN LGTGTGYSVLQMVQAMEKAS GKKIPYKVVARREGDVAACY ANPSLAQEELGWTAALGLDR MCEDLWRWQKQNPSGFGTQA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1). |
Additional Info
| Function | Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. |
| Protein Name | Udp-Glucose 4-EpimeraseGalactowaldenaseUdp-N-Acetylgalactosamine 4-EpimeraseUdp-Galnac 4-EpimeraseUdp-N-Acetylglucosamine 4-EpimeraseUdp-Glcnac 4-EpimeraseUdp-Galactose 4-Epimerase |
| Database Links | Reactome: R-HSA-5609977Reactome: R-HSA-70370 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Udp-Glucose 4-Epimerase antibodyAnti-Galactowaldenase antibodyAnti-Udp-N-Acetylgalactosamine 4-Epimerase antibodyAnti-Udp-Galnac 4-Epimerase antibodyAnti-Udp-N-Acetylglucosamine 4-Epimerase antibodyAnti-Udp-Glcnac 4-Epimerase antibodyAnti-Udp-Galactose 4-Epimerase antibodyAnti-GALE antibody |
Information sourced from Uniprot.org