Anti-UCP3 antibody (20-275) (STJ119262)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UCP3 (20-275) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UCP3 |
| Gene ID | 7352 |
| Uniprot ID | UCP3_HUMAN |
| Immunogen Region | 20-275 |
| Immunogen Sequence | AGTAACFADLVTFPLDTAKV RLQIQGENQAVQTARLVQYR GVLGTILTMVRTEGPCSPYN GLVAGLQRQMSFASIRIGLY DSVKQVYTPKGADNSSLTTR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-119 of human UCP3 (NP_073714.1). |
Additional Info
| Tissue Specificity | Only in skeletal muscle and heart. Also expressed in white and brown adipose tissues. Is more expressed in glycolytic than in oxidative skeletal muscles. |
| Function | Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity. |
| Protein Name | Putative Mitochondrial Transporter Ucp3Solute Carrier Family 25 Member 9Uncoupling Protein-3Ucp 3 |
| Database Links | Reactome: R-HSA-167826 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Putative Mitochondrial Transporter Ucp3 antibodyAnti-Solute Carrier Family 25 Member 9 antibodyAnti-Uncoupling Protein-3 antibodyAnti-Ucp 3 antibodyAnti-UCP3 antibodyAnti-SLC25A9 antibody |
Information sourced from Uniprot.org