Anti-UCP1 antibody [PT0090R] (STJA0039693)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Mitochondrial Brown Fat Uncoupling Protein 1 for use in WB, IHC, IF, IP and ELISA in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/IP/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0090R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1000WB 1:1000-5000IF 1:200-1000ELISA 1:5000-20000IP 1:50-200 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UCP1 |
| Gene ID | 7350 |
| Uniprot ID | UCP1_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. May undergo ubiquitin-mediated proteasomal degradation. |
| Function | Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. |
| Protein Name | Mitochondrial Brown Fat Uncoupling Protein 1Ucp 1Solute Carrier Family 25 Member 7Thermogenin |
| Database Links | Reactome: R-HSA-166187Reactome: R-HSA-167826Reactome: R-HSA-9844594 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Brown Fat Uncoupling Protein 1 antibodyAnti-Ucp 1 antibodyAnti-Solute Carrier Family 25 Member 7 antibodyAnti-Thermogenin antibodyAnti-UCP1 antibodyAnti-SLC25A7 antibodyAnti-UCP antibody |
Information sourced from Uniprot.org