| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UCHL3 (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UCHL3 |
| Gene ID: |
7347 |
| Uniprot ID: |
UCHL3_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human UCHL3 (NP_005993.1). |
| Immunogen Sequence: |
MEGQRWLPLEANPEVTNQFL KQLGLHPNWQFVDVYGMDPE LLSMVPRPVCAVLLLFPITE KYEVFRTEEEEKIKSQGQDV TSSVYFMKQTISNACGTIGL IHAIANNKDKMHFESGSTLK KFLEESVSMSPEERARYLEN YDAIRVTHETSAHEGQTEAP SIDEKVDLHFIALVHVDGHL YELDGRKPFPINHGETSDET LLEDAIEVCKKFMERDPDEL |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, and testis. |
| Function | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3Uch-L3Ubiquitin Thioesterase L3 |
| Database Links | Reactome: R-HSA-5689603Reactome: R-HSA-8866652Reactome: R-HSA-8951664 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 antibodyAnti-Uch-L3 antibodyAnti-Ubiquitin Thioesterase L3 antibodyAnti-UCHL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
