• Western blot analysis of lysates from HepG2 and Jurkat cells, using UBR1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HUVECcells using UBR1 antibody.
  • Western blot analysis of various cells using Ubr1 Polyclonal Antibody diluted at 1：2000. Secondary antibody was diluted at 1:20000

Anti-UBR1 antibody (821-870 aa) (STJ96173)

SKU:
STJ96173

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase UBR1 (821-870 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBR1
Gene ID: 197131
Uniprot ID: UBR1_HUMAN
Immunogen Region: 821-870 aa
Specificity: Ubr1 Polyclonal Antibody detects endogenous levels of Ubr1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human UBR1 at the amino acid range 821-870
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Protein Name E3 Ubiquitin-Protein Ligase Ubr1
N-Recognin-1
Ring-Type E3 Ubiquitin Transferase Ubr1
Ubiquitin-Protein Ligase E3-Alpha-1
Ubiquitin-Protein Ligase E3-Alpha-I
Database Links Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Ubr1 antibody
Anti-N-Recognin-1 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Ubr1 antibody
Anti-Ubiquitin-Protein Ligase E3-Alpha-1 antibody
Anti-Ubiquitin-Protein Ligase E3-Alpha-I antibody
Anti-UBR1 antibody

Information sourced from Uniprot.org

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