Anti-UBR1 antibody (1260-1500) {FITC} (STJ503454)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 1260-1500 on human UBR1 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-UBR1 (1260-1500) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.68-0.70 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150IHC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | UBR1 |
| Gene ID | 197131 |
| Uniprot ID | UBR1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 1260-1500 on human UBR1 protein. |
| Immunogen Region | 1260-1500 |
Additional Info
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively. Does not ubiquitinate proteins that are acetylated at the N-terminus. In contrast, it strongly binds methylated N-degrons. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr1N-Recognin-1Ubiquitin-Protein Ligase E3-Alpha-1Ubiquitin-Protein Ligase E3-Alpha-I |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ubr1 antibodyAnti-N-Recognin-1 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-1 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-I antibodyAnti-UBR1 antibody |
Information sourced from Uniprot.org