| Function | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation.required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). |
| Protein Name | Ubiquilin-2Chap1Dsk2 HomologProtein Linking Iap With Cytoskeleton 2Plic-2Hplic-2Ubiquitin-Like Product Chap1/Dsk2 |
| Database Links | Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmNucleusMembraneCytoplasmic VesicleAutophagosomeColocalizes With A Subset Of ProteasomesNamely Those That Are Cytoskeleton Associated Or Free In The CytosolAssociated With Fibers In Mitotic Cells |
| Alternative Antibody Names | Anti-Ubiquilin-2 antibodyAnti-Chap1 antibodyAnti-Dsk2 Homolog antibodyAnti-Protein Linking Iap With Cytoskeleton 2 antibodyAnti-Plic-2 antibodyAnti-Hplic-2 antibodyAnti-Ubiquitin-Like Product Chap1/Dsk2 antibodyAnti-UBQLN2 antibodyAnti-N4BP4 antibodyAnti-PLIC2 antibodyAnti-HRIHFB2157 antibody |
Information sourced from Uniprot.org
