| Function | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. |
| Protein Name | Ubinuclein-1Hira-Binding ProteinProtein Vt4Ubiquitously Expressed Nuclear Protein |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusNucleoplasmPml BodyCell JunctionTight JunctionLocalized As A Nuclear Speckled-Like Pattern In Proliferating Primary FibroblastsColocalizes With HiraPml And Sp100 In Pml Bodies Of Senescent CellsColocalizes With Tjp1 And Cldn1Detected Along The Upper Granular Cell Layer Of EpidermisWhen OverexpressedAccumulates In The Nucleus In Cells Showing Defective Cytokinesis |
| Alternative Antibody Names | Anti-Ubinuclein-1 antibodyAnti-Hira-Binding Protein antibodyAnti-Protein Vt4 antibodyAnti-Ubiquitously Expressed Nuclear Protein antibodyAnti-UBN1 antibody |
Information sourced from Uniprot.org
