• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-UBE4B antibody (Internal) (STJ96183)

SKU:
STJ96183

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ubiquitin conjugation factor E4 B (Internal) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBE4B
Gene ID: 10277
Uniprot ID: UBE4B_HUMAN
Immunogen Region: Internal
Specificity: UFD2 Polyclonal Antibody detects endogenous levels of UFD2 protein.
Immunogen: Synthesized peptide derived from the Internal region of human UFD2.
Post Translational Modifications Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
Function Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Protein Name Ubiquitin Conjugation Factor E4 B
Homozygously Deleted In Neuroblastoma 1
Ring-Type E3 Ubiquitin Transferase E4 B
Ubiquitin Fusion Degradation Protein 2
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Ubiquitin Conjugation Factor E4 B antibody
Anti-Homozygously Deleted In Neuroblastoma 1 antibody
Anti-Ring-Type E3 Ubiquitin Transferase E4 B antibody
Anti-Ubiquitin Fusion Degradation Protein 2 antibody
Anti-UBE4B antibody
Anti-HDNB1 antibody
Anti-KIAA0684 antibody
Anti-UFD2 antibody

Information sourced from Uniprot.org

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