| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBE4B (130-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBE4B |
| Gene ID: |
10277 |
| Uniprot ID: |
UBE4B_HUMAN |
| Immunogen Region: |
130-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 130-250 of human UBE4B (NP_006039.2). |
| Immunogen Sequence: |
EVDENDRREKRSLSDKEPSS GPEVSEEQALQLVCKIFRVS WKDRDRDVIFLSSLSAQFKQ NPKEVFSDFKDLIGQILMEV LMMSTQTRDENPFASLTATS QPIAAAARSPDRNLLLNTGS N |
| Tissue Specificity | Expressed in differentiated myotubes (at protein level). Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen. |
| Post Translational Modifications | Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7. |
| Function | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation. |
| Protein Name | Ubiquitin Conjugation Factor E4 BHomozygously Deleted In Neuroblastoma 1Ring-Type E3 Ubiquitin Transferase E4 BUbiquitin Fusion Degradation Protein 2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin Conjugation Factor E4 B antibodyAnti-Homozygously Deleted In Neuroblastoma 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase E4 B antibodyAnti-Ubiquitin Fusion Degradation Protein 2 antibodyAnti-UBE4B antibodyAnti-HDNB1 antibodyAnti-KIAA0684 antibodyAnti-UFD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
