| Tissue Specificity | Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. |
| Function | Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 Variant 2Ddvit 1Enterocyte Differentiation-Associated Factor 1Edaf-1Enterocyte Differentiation-Promoting Factor 1Edpf-1Mms2 HomologVitamin D3-Inducible Protein |
| Database Links | Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-5696395Reactome: R-HSA-69473Reactome: R-HSA-8866654Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 Variant 2 antibodyAnti-Ddvit 1 antibodyAnti-Enterocyte Differentiation-Associated Factor 1 antibodyAnti-Edaf-1 antibodyAnti-Enterocyte Differentiation-Promoting Factor 1 antibodyAnti-Edpf-1 antibodyAnti-Mms2 Homolog antibodyAnti-Vitamin D3-Inducible Protein antibodyAnti-UBE2V2 antibodyAnti-MMS2 antibodyAnti-UEV2 antibody |
Information sourced from Uniprot.org
