Anti-UBE2J1 antibody (39-89) (STJA0006317)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human UB2J1 AA range: 39-89
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin-conjugating enzyme E2 J1 (39-89) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBE2J1 |
| Gene ID | 51465 |
| Uniprot ID | UB2J1_HUMAN |
| Immunogen | Synthesized peptide derived from human UB2J1 AA range: 39-89 |
| Immunogen Region | 39-89 |
| Specificity | This antibody detects endogenous levels of human UB2J1 |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-184 in a cytosolic stress-dependent manner by MAP kinase p38 MAPKAPK2. Phosphorylated UBE2J1 is rapidly ubiquitinated and subsequently degraded by the proteasome. |
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133. (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 J1E2 Ubiquitin-Conjugating Enzyme J1Non-Canonical Ubiquitin-Conjugating Enzyme 1Ncube-1Yeast Ubiquitin-Conjugating Enzyme Ubc6 Homolog EHsubc6e |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane Protein |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 J1 antibodyAnti-E2 Ubiquitin-Conjugating Enzyme J1 antibodyAnti-Non-Canonical Ubiquitin-Conjugating Enzyme 1 antibodyAnti-Ncube-1 antibodyAnti-Yeast Ubiquitin-Conjugating Enzyme Ubc6 Homolog E antibodyAnti-Hsubc6e antibodyAnti-UBE2J1 antibodyAnti-NCUBE1 antibodyAnti-CGI-76 antibodyAnti-HSPC153 antibodyAnti-HSPC205 antibody |
Information sourced from Uniprot.org