Anti-UBA2 antibody [R08-6D4] (STJA0034971)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human UBA2
General Information
| Short Description | Rabbit monoclonal anti-UBA2 for use in WB, ICC, IF and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-6D4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | UBA2 |
| Gene ID | 10054 |
| Uniprot ID | SAE2_HUMAN |
| Immunogen | A synthetic peptide of human UBA2 |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking. |
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Antibody Names | Anti-Sumo-Activating Enzyme Subunit 2 antibodyAnti-Anthracycline-Associated Resistance Arx antibodyAnti-Ubiquitin-Like 1-Activating Enzyme E1b antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 2 antibodyAnti-UBA2 antibodyAnti-SAE2 antibodyAnti-UBLE1B antibodyAnti-HRIHFB2115 antibody |
Information sourced from Uniprot.org