Anti-UAP1 antibody (STJA0008248)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human UAP1
General Information
| Short Description | Rabbit polyclonal anti-UDP-N-acetylhexosamine pyrophosphorylase for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UAP1 |
| Gene ID | 6675 |
| Uniprot ID | UAP1_HUMAN |
| Immunogen | Synthesized peptide derived from human UAP1 |
| Specificity | This antibody detects endogenous levels of UAP1 at Human, Mouse |
Additional Info
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX1: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). |
| Protein Name | Udp-N-Acetylhexosamine PyrophosphorylaseAntigen XAgxProtein-Pyrophosphorylation EnzymeSperm-Associated Antigen 2Udp-N-Acetylgalactosamine PyrophosphorylaseUdp-N-Acetylglucosamine Pyrophosphorylase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | CytoplasmCytosolIn SpermatozoaLocalized To The Principal Piece Of The TailThe Neck Region Of The Head And To A Lesser ExtentThe Midpiece Of The Tail |
| Alternative Antibody Names | Anti-Udp-N-Acetylhexosamine Pyrophosphorylase antibodyAnti-Antigen X antibodyAnti-Agx antibodyAnti-Protein-Pyrophosphorylation Enzyme antibodyAnti-Sperm-Associated Antigen 2 antibodyAnti-Udp-N-Acetylgalactosamine Pyrophosphorylase antibodyAnti-Udp-N-Acetylglucosamine Pyrophosphorylase antibodyAnti-UAP1 antibodyAnti-SPAG2 antibody |
Information sourced from Uniprot.org