Anti-UAP1 antibody [R05-2X3] (STJA0036790)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human UAP1
General Information
| Short Description | Rabbit monoclonal anti-UAP1 for use in WB, IHC-P, ICC, IF, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-2X3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | UAP1 |
| Gene ID | 6675 |
| Uniprot ID | UAP1_HUMAN |
| Immunogen | A synthesized peptide derived from human UAP1 |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at low level in placenta, muscle and liver. Isoform AGX1: Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Isoform AGX2: Isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. |
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX1: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). |
| Protein Name | Udp-N-Acetylhexosamine PyrophosphorylaseAntigen XAgxProtein-Pyrophosphorylation EnzymeSperm-Associated Antigen 2Udp-N-Acetylgalactosamine PyrophosphorylaseUdp-N-Acetylglucosamine Pyrophosphorylase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | CytoplasmCytosolIn SpermatozoaLocalized To The Principal Piece Of The TailThe Neck Region Of The Head And To A Lesser ExtentThe Midpiece Of The Tail |
| Alternative Antibody Names | Anti-Udp-N-Acetylhexosamine Pyrophosphorylase antibodyAnti-Antigen X antibodyAnti-Agx antibodyAnti-Protein-Pyrophosphorylation Enzyme antibodyAnti-Sperm-Associated Antigen 2 antibodyAnti-Udp-N-Acetylgalactosamine Pyrophosphorylase antibodyAnti-Udp-N-Acetylglucosamine Pyrophosphorylase antibodyAnti-UAP1 antibodyAnti-SPAG2 antibody |
Information sourced from Uniprot.org