Anti-UACA antibody (1-90) (STJ111798)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UACA (1-90) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UACA |
| Gene ID | 55075 |
| Uniprot ID | UACA_HUMAN |
| Immunogen Region | 1-90 |
| Immunogen Sequence | MKSLKSRLRRQDVPGPASSG AAAASAHAADWNKYDDRLMK AAERGDVEKVTSILAKKGVN PGKLDVEGRSVFHVVTSKGN LECLNAILIH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2). |
Additional Info
| Tissue Specificity | Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. |
| Function | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation. |
| Protein Name | Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9627069 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonExpressed Diffusely In Cytoplasm |
| Alternative Antibody Names | Anti-Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats antibodyAnti-UACA antibodyAnti-KIAA1561 antibody |
Information sourced from Uniprot.org