Anti-Tyrosine Hydroxylase antibody [LNC1] (STJA0040396)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenTyrosine Hydroxylase purified from PC12 cells.
General Information
| Short Description | Mouse monoclonal anti-Tyrosine Hydroxylase for use in WB, IHC and ICC in All Mammalian samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Mouse |
| Reactivity | All Mammalian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | LNC1 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | Protein G purified culture supernatant. |
| Dilution Range | WB 1:1000IHC 1:1000ICC 1:500-1:1000 |
| Formulation | 100 Mu l in 10 mM Tris, 50 mM NaCl, 0.065% Sodium Azide pH 7.4 |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Th |
| Gene ID | 25085 |
| Uniprot ID | TY3H_RAT |
| Immunogen | Tyrosine Hydroxylase purified from PC12 cells. |
| Specificity | Specific for endogenous levels of the ~60 kDa tyrosine hydroxylase protein. |
Additional Info
| Function | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa. In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. |
| Protein Name | Tyrosine 3-MonooxygenaseTyrosine 3-HydroxylaseTh |
| Database Links | Reactome: R-RNO-209905 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusCell ProjectionAxonCytoplasmic VesicleSecretory VesicleSynaptic VesicleWhen Phosphorylated At Ser-19 Shows A Nuclear Distribution And When Phosphorylated At Ser-31 As Well As At Ser-40 Shows A Cytosolic DistributionExpressed In Dopaminergic Axons And Axon Terminals |
| Alternative Antibody Names | Anti-Tyrosine 3-Monooxygenase antibodyAnti-Tyrosine 3-Hydroxylase antibodyAnti-Th antibodyAnti-Th antibody |
Information sourced from Uniprot.org