Anti-Tyrosinase antibody IHC Human melanoma STJ180263

Anti-TYR antibody [T311] (STJ180263)

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STJ180263
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Short Description :Mouse monoclonal TYR antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :T311
Isotype:IgG2ak
Conjugation:Unconjugated
Purification:Affinity purified
Dilution Range:1:100‐200
Formulation:Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Storage Instruction:Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol:TYR
Gene ID:7299
Uniprot ID:TYRO_HUMAN
Immunogen:Recombinant tyrosinase protein
Specificity:Positive control: Melanoma
Post Translational Modifications Glycosylated.
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Protein Name Tyrosinase
Lb24-Ab
Monophenol Monooxygenase
Sk29-Ab
Tumor Rejection Antigen Ab
Database Links Reactome: R-HSA-5662702
Reactome: R-HSA-9824585
Cellular Localisation Melanosome Membrane
Single-Pass Type I Membrane Protein
Melanosome
Proper Trafficking To Melanosome Is Regulated By Sgsm2
Ankrd27
Rab9a
Rab32 And Rab38
Alternative Antibody Names Anti-Tyrosinase antibody
Anti-Lb24-Ab antibody
Anti-Monophenol Monooxygenase antibody
Anti-Sk29-Ab antibody
Anti-Tumor Rejection Antigen Ab antibody
Anti-TYR antibody

Information sourced from Uniprot.org

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