Anti-TYR antibody (20-340) (STJ26003)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TYR (20-340) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TYR |
| Gene ID | 7299 |
| Uniprot ID | TYRO_HUMAN |
| Immunogen Region | 20-340 |
| Immunogen Sequence | PWSGDRSPCGQLSGRGSCQN ILLSNAPLGPQFPFTGVDDR ESWPSVFYNRTCQCSGNFMG FNCGNCKFGFWGPNCTERRL LVRRNIFDLSAPEKDKFFAY LTLAKHTISSDYVIPIGTYG QMKNGSTPMFNDINIYDLFV WMHYYVSMDALLGGSEIWRD IDFAHEAPAFLPWHRLFLLR WEQEIQKLTGDENFTIPYWD WRDAEKCDICTDEYMGGQHP TNPNLLSPASFFSSWQIVC |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 20-340 of human Tyrosinase (NP_000363.1). |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Protein Name | TyrosinaseLb24-AbMonophenol MonooxygenaseSk29-AbTumor Rejection Antigen Ab |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-Tyrosinase antibodyAnti-Lb24-Ab antibodyAnti-Monophenol Monooxygenase antibodyAnti-Sk29-Ab antibodyAnti-Tumor Rejection Antigen Ab antibodyAnti-TYR antibody |
Information sourced from Uniprot.org