| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TYMS |
| Gene ID: | 7298 |
| Uniprot ID: | TYSY_HUMAN |
| Immunogen Region: | 1-313 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1). |
| Immunogen Sequence: | MPVAGSELPRRPLPPAAQER DAEPRPPHGELQYLGQIQHI LRCGVRKDDRTGTGTLSVFG MQARYSLRDEFPLLTTKRVF WKGVLEELLWFIKGSTNAKE LSSKGVKIWDANGSRDFLDS LGFSTREEGDLGPVYGFQWR HFGAEYRDMESDYSGQGVDQ LQRVIDTIKTNPDDRRIIMC AWNPRDLPLMALPPCHALCQ FYVVNSELSCQLYQRSGDMG LGVPFNIASYALLTYMIAH |
| Function | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
| Protein Name | Thymidylate SynthaseTsTsase |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-69205 |
| Cellular Localisation | NucleusCytoplasmMitochondrionMitochondrion MatrixMitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Thymidylate Synthase antibodyAnti-Ts antibodyAnti-Tsase antibodyAnti-TYMS antibodyAnti-TS antibodyAnti-OK antibodyAnti-SW-cl.29 antibody |
Information sourced from Uniprot.org