Anti-TWIST1 antibody (50-100) {Biotin} (STJ503439)

SKU:
STJ503439-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TWIST1 (50-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TWIST1
Gene ID: 7291
Uniprot ID: TWST1_HUMAN
Immunogen Region: 50-100
Immunogen: Synthetic peptide take within amino acid region 50-100 on human Twist-related protein 1.
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Protein Name Twist-Related Protein 1
Class A Basic Helix-Loop-Helix Protein 38
Bhlha38
H-Twist
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-8878166
Reactome: R-HSA-8939902
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Twist-Related Protein 1 antibody
Anti-Class A Basic Helix-Loop-Helix Protein 38 antibody
Anti-Bhlha38 antibody
Anti-H-Twist antibody
Anti-TWIST1 antibody
Anti-BHLHA38 antibody
Anti-TWIST antibody

Information sourced from Uniprot.org

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