Anti-TTLL12 antibody [4B2] (STJA0032632)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human TTLL12 produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-TTLL12 for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4B2 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.73 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100ICC 1:100-1:200FC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TTLL12 |
| Gene ID | 23170 |
| Uniprot ID | TTL12_HUMAN |
| Immunogen | Full length human recombinant protein of human TTLL12 produced in 293T cell. |
Additional Info
| Tissue Specificity | Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions. |
| Function | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE. |
| Protein Name | Tubulin--Tyrosine Ligase-Like Protein 12Inactive Tubulin--Tyrosine Ligase-Like Protein 12 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmMidbodyCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleNucleusPredominantly Localizes In The CytoplasmPartially Colocalizes With Vimentin In Prostate Cancer Cells |
| Alternative Antibody Names | Anti-Tubulin--Tyrosine Ligase-Like Protein 12 antibodyAnti-Inactive Tubulin--Tyrosine Ligase-Like Protein 12 antibodyAnti-TTLL12 antibodyAnti-KIAA0153 antibody |
Information sourced from Uniprot.org