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Anti-TTF1 antibody [SM5074] (STJA0005074)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenKLH conjugated Synthetic peptide corresponding to Human TTF-1
General Information
| Short Description | Mouse monoclonal anti-TTF1 for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5074 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC/IF (H, M, R) 1:500-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | NKX2-1 |
| Gene ID | 7080 |
| Uniprot ID | NKX21_HUMAN |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Human TTF-1 |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1Homeobox Protein Nk-2 Homolog AThyroid Nuclear Factor 1Thyroid Transcription Factor 1Ttf-1Thyroid-Specific Enhancer-Binding ProteinT/Ebp |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibodyAnti-Homeobox Protein Nk-2 Homolog A antibodyAnti-Thyroid Nuclear Factor 1 antibodyAnti-Thyroid Transcription Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Thyroid-Specific Enhancer-Binding Protein antibodyAnti-T/Ebp antibodyAnti-NKX2-1 antibodyAnti-NKX2A antibodyAnti-TITF1 antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org