| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Tetraspanin-5 (113-163 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TSPAN5 |
| Gene ID: | 10098 |
| Uniprot ID: | TSN5_HUMAN |
| Immunogen Region: | 113-163 aa |
| Specificity: | This antibody detects endogenous levels of human TSN5 |
| Immunogen: | Synthesized peptide derived from the human TSN5 at the amino acid range 113-163 |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration. |
| Protein Name | Tetraspanin-5Tspan-5Tetraspan Net-4Transmembrane 4 Superfamily Member 9 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tetraspanin-5 antibodyAnti-Tspan-5 antibodyAnti-Tetraspan Net-4 antibodyAnti-Transmembrane 4 Superfamily Member 9 antibodyAnti-TSPAN5 antibodyAnti-TM4SF9 antibody |
Information sourced from Uniprot.org
