Anti-TSHZ3 antibody (STJ191743)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Teashirt homolog 3 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TSHZ3 |
| Gene ID | 57616 |
| Uniprot ID | TSH3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TSH3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation. |
| Protein Name | Teashirt Homolog 3Zinc Finger Protein 537 |
| Database Links | |
| Cellular Localisation | NucleusCell ProjectionGrowth ConeColocalizes With Apbb1 In Axonal Growth ConeColocalizes With Apbb1 In The Nucleus |
| Alternative Antibody Names | Anti-Teashirt Homolog 3 antibodyAnti-Zinc Finger Protein 537 antibodyAnti-TSHZ3 antibodyAnti-KIAA1474 antibodyAnti-TSH3 antibodyAnti-ZNF537 antibody |
Information sourced from Uniprot.org