Anti-TSHR/LGR3 antibody [M22] (STJA0027898)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Thyrotropin Receptor antibody for use in ELISA, FC, IP and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/IP/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M22 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 4.3 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | TSHR |
| Gene ID | 7253 |
| Uniprot ID | TSHR_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. |
| Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Protein Name | Thyrotropin ReceptorThyroid-Stimulating Hormone ReceptorTsh-R |
| Database Links | Reactome: R-HSA-375281Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Thyrotropin Receptor antibodyAnti-Thyroid-Stimulating Hormone Receptor antibodyAnti-Tsh-R antibodyAnti-TSHR antibodyAnti-LGR3 antibody |
Information sourced from Uniprot.org