Anti-TSHR antibody (21-253) (STJ28864)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TSHR (21-253) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TSHR |
| Gene ID | 7253 |
| Uniprot ID | TSHR_HUMAN |
| Immunogen Region | 21-253 |
| Immunogen Sequence | GMGCSSPPCECHQEEDFRVT CKDIQRIPSLPPSTQTLKLI ETHLRTIPSHAFSNLPNISR IYVSIDVTLQQLESHSFYNL SKVTHIEIRNTRNLTYIDPD ALKELPLLKFLGIFNTGLKM FPDLTKVYSTDIFFILEITD NPYMTSIPVNAFQGLCNETL TLKLYNNGFTSVQGYAFNGT KLDAVYLNKNKYLTVIDKDA FGGVYSGPSLLLPLGRKSLS FETQKAPRSSMPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 21-253 of human TSHR (NP_001018046.1). |
Additional Info
| Tissue Specificity | Expressed in thyroide cells (at protein level). Expressed in the thyroid. |
| Post Translational Modifications | Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. |
| Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Protein Name | Thyrotropin ReceptorThyroid-Stimulating Hormone ReceptorTsh-R |
| Database Links | Reactome: R-HSA-375281Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Thyrotropin Receptor antibodyAnti-Thyroid-Stimulating Hormone Receptor antibodyAnti-Tsh-R antibodyAnti-TSHR antibodyAnti-LGR3 antibody |
Information sourced from Uniprot.org