| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TSC22 domain family protein 3 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TSC22D3 |
| Gene ID: |
1831 |
| Uniprot ID: |
T22D3_HUMAN |
| Specificity: |
T22D3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. Isoform 1: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
| Protein Name | Tsc22 Domain Family Protein 3Dsip-Immunoreactive PeptideProtein DipHdipDelta Sleep-Inducing Peptide ImmunoreactorGlucocorticoid-Induced Leucine Zipper ProteinGilzTsc-22-Like ProteinTsc-22-Related ProteinTsc-22r |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalization Depends On Differentiation Status Of MyoblastsIn Undifferentiated MyoblastsLocalizes To The CytoplasmBut In Differentiating MyoblastLocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Tsc22 Domain Family Protein 3 antibodyAnti-Dsip-Immunoreactive Peptide antibodyAnti-Protein Dip antibodyAnti-Hdip antibodyAnti-Delta Sleep-Inducing Peptide Immunoreactor antibodyAnti-Glucocorticoid-Induced Leucine Zipper Protein antibodyAnti-Gilz antibodyAnti-Tsc-22-Like Protein antibodyAnti-Tsc-22-Related Protein antibodyAnti-Tsc-22r antibodyAnti-TSC22D3 antibodyAnti-DSIPI antibodyAnti-GILZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TSC22D3 knockout (KO) 293T cells, using [KO Validated] TSC22D3 Rabbit polyclonal antibody (STJ11100787) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89723/358204/STJ11100787_1__85282.1713122525.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TSC22D3 knockout (KO) 293T cells, using [KO Validated] TSC22D3 Rabbit polyclonal antibody (STJ11100787) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
