Anti-TrpV5 antibody [R03-7A4] (STJA0034957)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human TRPV5
General Information
| Short Description | Rabbit monoclonal anti-TrpV5 for use in WB and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-7A4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TRPV5 |
| Gene ID | 56302 |
| Uniprot ID | TRPV5_HUMAN |
| Immunogen | A synthetic peptide of human TRPV5 |
Additional Info
| Tissue Specificity | Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. |
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5Trpv5Calcium Transport Protein 2Cat2Epithelial Calcium Channel 1EcacEcac1Osm-9-Like Trp Channel 3Otrpc3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinColocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular CellsThe Expression Of The Glycosylated Form In The Cell Membrane Is Increased In The Presence Of Wnk3 |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibodyAnti-Trpv5 antibodyAnti-Calcium Transport Protein 2 antibodyAnti-Cat2 antibodyAnti-Epithelial Calcium Channel 1 antibodyAnti-Ecac antibodyAnti-Ecac1 antibodyAnti-Osm-9-Like Trp Channel 3 antibodyAnti-Otrpc3 antibodyAnti-TRPV5 antibodyAnti-ECAC1 antibody |
Information sourced from Uniprot.org