| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPV5 (655-729) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPV5 |
| Gene ID: |
56302 |
| Uniprot ID: |
TRPV5_HUMAN |
| Immunogen Region: |
655-729 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 655-729 of human TRPV5 (NP_062815.3). |
| Immunogen Sequence: |
DKEDDQEHPSEKQPSGAESG TLARASLALPTSSLSRTASQ SSSHRGWEILRQNTLGHLNL GLNLSEGDGEE |
| Tissue Specificity | Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. |
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5Trpv5Calcium Transport Protein 2Cat2Epithelial Calcium Channel 1EcacEcac1Osm-9-Like Trp Channel 3Otrpc3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinColocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular CellsThe Expression Of The Glycosylated Form In The Cell Membrane Is Increased In The Presence Of Wnk3 |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibodyAnti-Trpv5 antibodyAnti-Calcium Transport Protein 2 antibodyAnti-Cat2 antibodyAnti-Epithelial Calcium Channel 1 antibodyAnti-Ecac antibodyAnti-Ecac1 antibodyAnti-Osm-9-Like Trp Channel 3 antibodyAnti-Otrpc3 antibodyAnti-TRPV5 antibodyAnti-ECAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
