| Host: |
Sheep |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Sheep polyclonal antibody anti-TRPV5 (610-660 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Trpv5 |
| Gene ID: |
194352 |
| Uniprot ID: |
TRPV5_MOUSE |
| Immunogen Region: |
610-660 aa |
| Specificity: |
Specific for TRPV5. |
| Immunogen: |
A synthetic peptide from aa region 610-660 of mouse TRPV5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat. |
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5Trpv5Calcium Transport Protein 2Cat2Epithelial Calcium Channel 1Ecac1Osm-9-Like Trp Channel 3Otrpc3 |
| Database Links | Reactome: R-MMU-3295583 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinColocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular Cells |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibodyAnti-Trpv5 antibodyAnti-Calcium Transport Protein 2 antibodyAnti-Cat2 antibodyAnti-Epithelial Calcium Channel 1 antibodyAnti-Ecac1 antibodyAnti-Osm-9-Like Trp Channel 3 antibodyAnti-Otrpc3 antibodyAnti-Trpv5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
