Anti-TRPV3 antibody (STJ13100492)
SPECIFICATIONS
ClonalityPolyclonal
HostGuinea Pig
ConjugationUnconjugated
ImmunogenA synthetic peptide rat TRPV3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
General Information
| Short Description | Guinea Pig polyclonal anti-TRPV3 for use in IHC and WB in Rat, Mouse and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Guinea Pig |
| Reactivity | Rat/Mouse/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC, WB. A dilution of 1:500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Trpv3 |
| Gene ID | 246788 |
| Uniprot ID | TRPV3_MOUSE |
| Immunogen | A synthetic peptide rat TRPV3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse. |
| Specificity | Specific for TRPV3. |
Additional Info
| Function | Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 3Trpv3 |
| Database Links | Reactome: R-MMU-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmLysosomeTargeted To Lysosome For Degradation In A Snx11-Dependent Manner |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 3 antibodyAnti-Trpv3 antibodyAnti-Trpv3 antibody |
Information sourced from Uniprot.org