• Western blot analysis of extracts of various cell lines, using TRPV3 antibody (STJ111330) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-TRPV3 antibody (400-500) (STJ111330)

SKU:
STJ111330

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-TRPV3 (400-500) is suitable for use in Western Blot.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store in a freezer at-20°C and avoid freeze-thaw cycles.
Gene Symbol: TRPV3
Gene ID: 162514
Uniprot ID: TRPV3_HUMAN
Immunogen Region: 400-500
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPV3 (NP_659505.1).
Tissue Specificity Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
Function Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Protein Name Transient Receptor Potential Cation Channel Subfamily V Member 3
Trpv3
Vanilloid Receptor-Like 3
Vrl-3
Database Links Reactome: R-HSA-3295583
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily V Member 3 antibody
Anti-Trpv3 antibody
Anti-Vanilloid Receptor-Like 3 antibody
Anti-Vrl-3 antibody
Anti-TRPV3 antibody

Information sourced from Uniprot.org

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