• STJ70049 (4µg/ml) staining of paraffin embedded Mouse Hippocampus. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Similar results were obtained after antigen retrieval at pH9.
  • STJ70049 Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing nuclear and cytoplasmic staining. Actin filaments were stained with phalloidin (red) and the nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Anti-TRPM7/LTRPC7 antibody (C-Term) (STJ70049)

SKU:
STJ70049-100

£303.50
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Host: Goat
Applications: Pep-ELISA/IHC/IF
Reactivity: Human/Mouse/Rat/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TRPM7/LTRPC7 (C-Term) is suitable for use in ELISA, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-4-6µg/ml
IF-Strong expression of the protein seen in the cytoplasm and nuclei of U2OS cells. 10µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TRPM7
Gene ID: 54822
Uniprot ID: TRPM7_HUMAN
Immunogen Region: C-Term
Accession Number: NP_060142.3; NP_001288141.1
Immunogen Sequence: TKESESTNSVRLML
Function Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 7
Channel-Kinase 1
Long Transient Receptor Potential Channel 7
Ltrpc-7
Ltrpc7
Database Links Reactome: R-HSA-3295583
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 7 antibody
Anti-Channel-Kinase 1 antibody
Anti-Long Transient Receptor Potential Channel 7 antibody
Anti-Ltrpc-7 antibody
Anti-Ltrpc7 antibody
Anti-TRPM7 antibody
Anti-CHAK1 antibody
Anti-LTRPC7 antibody

Information sourced from Uniprot.org

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