![Anti-TRPM4/LTRPC4 antibody [SAA0760] (STJA0019604)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/188320/412619/STJA0019604-WB-1-anti-TRPM4__46509.1749229348.jpg?c=1 "Anti-TRPM4/LTRPC4 antibody [SAA0760] (STJA0019604)")
![Anti-TRPM4/LTRPC4 antibody [SAA0760] (STJA0019604)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/188320/412619/STJA0019604-WB-1-anti-TRPM4__46509.1749229348.jpg?c=1 "Anti-TRPM4/LTRPC4 antibody [SAA0760] (STJA0019604)")
Anti-TRPM4/LTRPC4 antibody [SAA0760] (STJA0019604)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeVHH-hFc
General Information
| Short Description | Human monoclonal Transient Receptor Potential Cation Channel Subfamily M Member 4 antibody for use in ELISA and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0760 |
| Isotype | VHH-hFc |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | TRPM4 |
| Gene ID | 54795 |
| Uniprot ID | TRPM4_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1. |
| Function | Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation. Isoform 2: Lacks channel activity. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 4Htrpm4Calcium-Activated Non-Selective Cation Channel 1Long Transient Receptor Potential Channel 4Ltrpc-4Ltrpc4Melastatin-4 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-9717207 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumGolgi ApparatusIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 4 antibodyAnti-Htrpm4 antibodyAnti-Calcium-Activated Non-Selective Cation Channel 1 antibodyAnti-Long Transient Receptor Potential Channel 4 antibodyAnti-Ltrpc-4 antibodyAnti-Ltrpc4 antibodyAnti-Melastatin-4 antibodyAnti-TRPM4 antibodyAnti-LTRPC4 antibody |
Information sourced from Uniprot.org