Anti-TRPM3 antibody (STJ13102371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the 4th cytoplasmic loop of human TRPM3 (Melastatin-2, LTrpC3, MLSN2, GON-2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-TRPM3 for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TRPM3 |
| Gene ID | 80036 |
| Uniprot ID | TRPM3_HUMAN |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human TRPM3 (Melastatin-2, LTrpC3, MLSN2, GON-2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Specificity | Specific for TRPM3. |
Additional Info
| Function | Constitutively active, non-selective divalent cation-conducting channel that is permeable to Ca(2+), Mn(2+), and Mg(2+), with a high permeability for Ca(2+). However, can be enhanced by increasing temperature and by ligands, including the endogenous neurosteroid pregnenolone sulfate and sphingosine-1 and suppressed by intracellular Mg(2+). Implicated in a variety of cellular processes, including insulin/peptide secretion, vascular constriction and dilation, noxious heat sensing, inflammatory and spontaneous pain sensitivity. In neurons of the dorsal root ganglia, functions as thermosensitive channel for the detection of noxious heat and spontaneous pain. Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion. Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. Forms heteromultimeric ion channels with TRPM1 which are permeable for Ca(2+) and Zn(2+) ions. Exists as multiple splice variants which differ significantly in their biophysical properties. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 3Long Transient Receptor Potential Channel 3Ltrpc-3Ltrpc3Melastatin-2Mlsn2 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 3 antibodyAnti-Long Transient Receptor Potential Channel 3 antibodyAnti-Ltrpc-3 antibodyAnti-Ltrpc3 antibodyAnti-Melastatin-2 antibodyAnti-Mlsn2 antibodyAnti-TRPM3 antibodyAnti-KIAA1616 antibodyAnti-LTRPC3 antibody |
Information sourced from Uniprot.org