Western blot analysis of extracts of mouse pancreas, using TRPC6 antibody (STJ110454) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.

Anti-TRPC6 antibody (466-565) (STJ110454)

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STJ110454
£112.50 - £524.50
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPC6
Gene ID: 7225
Uniprot ID: TRPC6_HUMAN
Immunogen Region: 466-565
Specificity: A synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_004612.2).
Immunogen Sequence: EGTKLLPNETSTDNAKQLFR MKTSCFSWMEMLIISWVIGM IWAECKEIWTQGPKEYLFEL WNMLDFGMLAIFAASFIARF MAFWHASKAQSIIDANDTLK
Tissue Specificity Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Post Translational Modifications Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.
Function Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Protein Name Short Transient Receptor Potential Channel 6
Trpc6
Transient Receptor Protein 6
Trp-6
Database Links Reactome: R-HSA-114508
Reactome: R-HSA-139853
Reactome: R-HSA-3295583
Reactome: R-HSA-418890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Short Transient Receptor Potential Channel 6 antibody
Anti-Trpc6 antibody
Anti-Transient Receptor Protein 6 antibody
Anti-Trp-6 antibody
Anti-TRPC6 antibody
Anti-TRP6 antibody

Information sourced from Uniprot.org

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