| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRPC6 |
| Gene ID: | 7225 |
| Uniprot ID: | TRPC6_HUMAN |
| Immunogen Region: | 466-565 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_004612.2). |
| Immunogen Sequence: | EGTKLLPNETSTDNAKQLFR MKTSCFSWMEMLIISWVIGM IWAECKEIWTQGPKEYLFEL WNMLDFGMLAIFAASFIARF MAFWHASKAQSIIDANDTLK |
| Tissue Specificity | Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. |
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6 Trpc6 Transient Receptor Protein 6 Trp-6 |
| Database Links | Reactome: R-HSA-114508 Reactome: R-HSA-139853 Reactome: R-HSA-3295583 Reactome: R-HSA-418890 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibody Anti-Trpc6 antibody Anti-Transient Receptor Protein 6 antibody Anti-Trp-6 antibody Anti-TRPC6 antibody Anti-TRP6 antibody |
Information sourced from Uniprot.org