Anti-TRPC6 antibody (10-60 aa) (STJ13100410)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 10-60 of rat TRPC6 conjugated to blue carrier protein was used as the antigen. The antigen is homologous with the corresponding sequence in mouse.
General Information
| Short Description | Rabbit polyclonal anti-TRPC6 (10-60 aa) for use in WB in Mouse, Rat, Human and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | WB. A dilution of 1: 4000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TRPC6 |
| Gene ID | 7225 |
| Uniprot ID | TRPC6_HUMAN |
| Immunogen | A synthetic peptide from aa region 10-60 of rat TRPC6 conjugated to blue carrier protein was used as the antigen. The antigen is homologous with the corresponding sequence in mouse. |
| Immunogen Region | 10-60 aa |
| Specificity | Specific for TRPC6. |
Additional Info
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6Trpc6Transient Receptor Protein 6Trp-6 |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibodyAnti-Trpc6 antibodyAnti-Transient Receptor Protein 6 antibodyAnti-Trp-6 antibodyAnti-TRPC6 antibodyAnti-TRP6 antibody |
Information sourced from Uniprot.org