| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. |
| Protein Name | Short Transient Receptor Potential Channel 4-Associated ProteinTrp4-Associated ProteinTrpc4-Associated ProteinProtein Tap1Tnf-Receptor Ubiquitous Scaffolding/Signaling ProteinProtein Truss |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4-Associated Protein antibodyAnti-Trp4-Associated Protein antibodyAnti-Trpc4-Associated Protein antibodyAnti-Protein Tap1 antibodyAnti-Tnf-Receptor Ubiquitous Scaffolding/Signaling Protein antibodyAnti-Protein Truss antibodyAnti-TRPC4AP antibodyAnti-C20orf188 antibodyAnti-TRRP4AP antibody |
Information sourced from Uniprot.org
