Anti-TRPC4 antibody (4th Cytoplasmic Loop) (STJ13102426)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-TRPC4 (4th Cytoplasmic Loop) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TRPC4 |
| Gene ID | 7223 |
| Uniprot ID | TRPC4_HUMAN |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 4th Cytoplasmic Loop |
| Specificity | Specific for TRPC4. |
Additional Info
| Post Translational Modifications | Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Forms a homomeric ion channel or a heteromeric ion channel with TRPC1.the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel. Also permeable to monovalent ions including sodium, lithium and cesium ions. Isoform Beta: Forms a receptor-activated non-selective calcium permeant cation channel. |
| Protein Name | Short Transient Receptor Potential Channel 4Trpc4Trp-Related Protein 4Htrp-4Htrp4 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEnhanced Insertion Into The Cell Membrane After Activation Of The Egf ReceptorIsoform Beta: Cell Membrane |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4 antibodyAnti-Trpc4 antibodyAnti-Trp-Related Protein 4 antibodyAnti-Htrp-4 antibodyAnti-Htrp4 antibodyAnti-TRPC4 antibody |
Information sourced from Uniprot.org