Anti-TRMT2B antibody (1-250) (STJ26358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRMT2B (1-250) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRMT2B |
| Gene ID | 79979 |
| Uniprot ID | TRM2B_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MAGLKRRVPLHSLRYFISMV GLFSKPGLLPWYARNPPGWS QLFLGTVCKGDFTRVIATKC QKGQKSQKKPSHLGPLDGSW QERLADVVTPLWRLSYEEQL KVKFAAQKKILQRLESYIQM LNGVSVTTAVPKSERLSCLL HPIIPSPVINGYRNKSTFSV NRGPDGNPKTVGFYLGTWRD GNVVCVQSNHLKNIPEKHSQ VAQYYEVFLRQSPLEPCLVF HEGGYWRELTVRTNSQGHT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human TRMT2B (NP_079193.2). |
Additional Info
| Function | Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA. Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs. Specifically methylates the uridine in position 429 of 12S rRNA (m5U429). Does not affect RNA stability or mitochondrial translation. |
| Protein Name | TrnaUracil-5--Methyltransferase Homolog BTrm2 Homolog BRrnaUracil-5--Methyltransferase Trmt2b |
| Database Links | |
| Cellular Localisation | MitochondrionIsoform 1: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Uracil-5--Methyltransferase Homolog B antibodyAnti-Trm2 Homolog B antibodyAnti-Rrna antibodyAnti-Uracil-5--Methyltransferase Trmt2b antibodyAnti-TRMT2B antibodyAnti-CXorf34 antibody |
Information sourced from Uniprot.org