Anti-TRMT112 antibody (1-125) (STJ116522)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRMT112 (1-125) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRMT112 |
| Gene ID | 51504 |
| Uniprot ID | TR112_HUMAN |
| Immunogen Region | 1-125 |
| Immunogen Sequence | MKLLTHNLLSSHVRGVGSRG FPLRLQATEVRICPVEFNPN FVARMIPKVEWSAFLEAADN LRLIQVPKGPVEGYEENEEF LRTMHHLLLEVEVIEGTLQC PESGRMFPISRGIPNMLLSE EETES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human TRMT112 (NP_057488.1). |
Additional Info
| Function | Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. |
| Protein Name | Multifunctional Methyltransferase Subunit Trm112-Like ProteinTrna Methyltransferase 112 Homolog |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-6782315Reactome: R-HSA-6790901Reactome: R-HSA-72764 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionLocalizes To A Polarized Perinuclear StructureOverlapping Partially With The Golgi And Lysosomes |
| Alternative Antibody Names | Anti-Multifunctional Methyltransferase Subunit Trm112-Like Protein antibodyAnti-Trna Methyltransferase 112 Homolog antibodyAnti-TRMT112 antibodyAnti-AD-001 antibodyAnti-HSPC152 antibodyAnti-HSPC170 antibody |
Information sourced from Uniprot.org