Anti-TrkC antibody (780-830 aa) (STJ13100417)

SKU:
STJ13100417-100

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Host: Rabbit
Applications: IHC/WB
Reactivity: Rat/Mouse/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TrkC (780-830 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: NTRK3
Gene ID: 4916
Uniprot ID: NTRK3_HUMAN
Immunogen Region: 780-830 aa
Specificity: Specific for TrkC.
Immunogen: A synthetic peptide from aa region 780-830 of the cytoplasmic domain of human TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Post Translational Modifications Ligand-mediated auto-phosphorylation.
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Protein Name Nt-3 Growth Factor Receptor
Gp145-Trkc
Trk-C
Neurotrophic Tyrosine Kinase Receptor Type 3
Trkc Tyrosine Kinase
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-388844
Reactome: R-HSA-6811558
Reactome: R-HSA-9034013
Reactome: R-HSA-9034015
Reactome: R-HSA-9034793
Reactome: R-HSA-9034864
Reactome: R-HSA-9603381
Reactome: R-HSA-9603505
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Nt-3 Growth Factor Receptor antibody
Anti-Gp145-Trkc antibody
Anti-Trk-C antibody
Anti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibody
Anti-Trkc Tyrosine Kinase antibody
Anti-NTRK3 antibody
Anti-TRKC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance