| Host: |
Rabbit |
| Applications: |
WB/IHC/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIP4 (282-581) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IP 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIP4 |
| Gene ID: |
9325 |
| Uniprot ID: |
TRIP4_HUMAN |
| Immunogen Region: |
282-581 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 282-581 of human TRIP4 (NP_057297.2). |
| Immunogen Sequence: |
VIDDESDYFASDSNQWLSKL ERETLQKREEELRELRHASR LSKKVTIDFAGRKILEEENS LAEYHSRLDETIQAIANGTL NQPLTKLDRSSEEPLGVLVN PNMYQSPPQWVDHTGAASQK KAFRSSGFGLEFNSFQHQLR IQDQEFQEGFDGGWCLSVHQ PWASLLVRGIKRVEGRSWYT PHRGRLWIAATAKKPSPQEV SELQATYRLLRGKDVEFPND YPSGCLLGCVDLIDCLSQK |
| Post Translational Modifications | Phosphorylated by NEK6. Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription. |
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. |
| Protein Name | Activating Signal Cointegrator 1Asc-1Thyroid Receptor-Interacting Protein 4Tr-Interacting Protein 4Trip-4 |
| Cellular Localisation | NucleusCytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Under Conditions Of Serum DeprivationColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 antibodyAnti-Asc-1 antibodyAnti-Thyroid Receptor-Interacting Protein 4 antibodyAnti-Tr-Interacting Protein 4 antibodyAnti-Trip-4 antibodyAnti-TRIP4 antibodyAnti-RQT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
