Anti-TRIM71 antibody (390-402) (STJ72181)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TRIM71 (390-402) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 100kDa band observed in lysates of the cell lines HEK293 and NIH3T3 (calculated MW of 93.4kDa according to Human NP_001034200.1 and 92.1kDa according to Mouse NP_001035968.1). Th |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM71 |
| Gene ID | 131405 |
| Uniprot ID | LIN41_HUMAN |
| Accession Number | NP_001034200.1 |
| Immunogen Region | 390-402 |
| Immunogen Sequence | RQVKAKSLYLQVE |
Additional Info
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim71Protein Lin-41 HomologRing-Type E3 Ubiquitin Transferase Trim71Tripartite Motif-Containing Protein 71 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim71 antibodyAnti-Protein Lin-41 Homolog antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim71 antibodyAnti-Tripartite Motif-Containing Protein 71 antibodyAnti-TRIM71 antibodyAnti-LIN41 antibody |
Information sourced from Uniprot.org