| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin ligase TRIM40 (85-135 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM40 |
| Gene ID: |
135644 |
| Uniprot ID: |
TRI40_HUMAN |
| Immunogen Region: |
85-135 aa |
| Specificity: |
This antibody detects endogenous levels of TRI40 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human TRI40 at the amino acid range 85-135 |
| Function | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. |
| Protein Name | E3 Ubiquitin Ligase Trim40Probable E3 Nedd8-Protein LigaseRing Finger Protein 35 |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Trim40 antibodyAnti-Probable E3 Nedd8-Protein Ligase antibodyAnti-Ring Finger Protein 35 antibodyAnti-TRIM40 antibodyAnti-RNF35 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
