Anti-TRIM40 antibody (85-135 aa) (STJ194814)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TRI40 at the amino acid range 85-135
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin ligase TRIM40 (85-135 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM40 |
| Gene ID | 135644 |
| Uniprot ID | TRI40_HUMAN |
| Immunogen | Synthesized peptide derived from the human TRI40 at the amino acid range 85-135 |
| Immunogen Region | 85-135 aa |
| Specificity | This antibody detects endogenous levels of TRI40 at Human/Mouse/Rat |
Additional Info
| Function | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. |
| Protein Name | E3 Ubiquitin Ligase Trim40Probable E3 Nedd8-Protein LigaseRing Finger Protein 35 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Trim40 antibodyAnti-Probable E3 Nedd8-Protein Ligase antibodyAnti-Ring Finger Protein 35 antibodyAnti-TRIM40 antibodyAnti-RNF35 antibody |
Information sourced from Uniprot.org